Proteínas importantes para la invasión de Babesia bovis a las células huésped
Titulo:

Proteínas importantes para la invasión de Babesia bovis a las células huésped
.

Sumario:

Introducción. La babesiosis bovina es causada por parásitos Apicomplexa del género Babesia, siendo Babesia bovis la especie asociada con cuadros clínicos más graves de la enfermedad. La invasión de B. bovis a los eritrocitos bovinos implica la interacción entre moléculas de los merozoítos del parásito con receptores de las células huésped. Por ende, conocer las proteínas involucradas en este proceso supone un importante paso para entender la biología del parásito. Objetivo. Describir las principales moléculas implicadas en el proceso de invasión de B. bovis a eritrocitos bovinos. Metodología. Se realizó una búsqueda en NCBI, Medline, LILACS y SciELO usando los términos: “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving... Ver más

Guardado en:

Revista Investigación en Salud Universidad de Boyacá

2389-7325

2539-2018

Cuy Chaparro, Laura Esperanza

Camargo Mancipe, Anny

Gómez Rodríguez, Alida Marcela

Reyes Santofimio, César

Moreno Pérez, Darwin Andrés

UNIVERSIDAD DE BOYACÁ

10.24267/23897325.475

8

2021-02-05

75

90

Colombia

Babesia bovis

Babesiosis

interacciones huésped-parásito

proteínas

control de infección

Revista Investigación en Salud Universidad de Boyacá - 2021

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

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spelling Proteínas importantes para la invasión de Babesia bovis a las células huésped
Important proteins for Babesia bovis invasion to host cells
Introducción. La babesiosis bovina es causada por parásitos Apicomplexa del género Babesia, siendo Babesia bovis la especie asociada con cuadros clínicos más graves de la enfermedad. La invasión de B. bovis a los eritrocitos bovinos implica la interacción entre moléculas de los merozoítos del parásito con receptores de las células huésped. Por ende, conocer las proteínas involucradas en este proceso supone un importante paso para entender la biología del parásito. Objetivo. Describir las principales moléculas implicadas en el proceso de invasión de B. bovis a eritrocitos bovinos. Metodología. Se realizó una búsqueda en NCBI, Medline, LILACS y SciELO usando los términos: “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving junction”, “B. bovis AND Vaccine candidates”. 61 publicaciones disponibles en inglés que describen el estudio de las anteriores proteínas y su participación en la invasión los cuales han sido publicados hasta mayo 2020 se revisaron completamente. Resultados: Siendo el proceso de invasión a eritrocitos bovinos clave para la patogénesis de la babesiosis bovina, se hizo una revisión donde se encontraron 3 proteínas de B. bovis que participan en el reconocimiento e invasión a las células diana: MSA-1, AMA-1 y RON2. Sin embargo, los detalles a nivel molecular para las interacciones inter e intramoleculares aún no se han dilucidado por completo. Conclusiones. Conocer las moléculas involucradas en las interacciones parásito-hospedero permitirá comprender cómo ocurre el proceso de invasión de B. bovis a los eritrocitos y así evaluar su futura utilidad como componente de una estrategia de control efectiva contra esta parasitosis.
Introduction. Bovine babesiosis is caused by Apicomplexas parasites of the genus Babesia, Babesia bovis being the species associated with the most serious clinical conditions of the disease. B. bovis invasion into the bovine erythrocytes involves the interaction between the parasites merozoites molecules with host cell receptors. Therefore, knowing the proteins involved in the invasion process will enable understanding the parasite biology. Objective. To describe the important molecules involved in the B. bovis invasion process to bovine erythrocytes. Methodology. A search was made on NCBI, Medline, LILACS and SciELO databases using keywords as “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving junction”, “B. bovis AND Vaccine candidates”. 61 studies written in English describing the study for proteins that take place during invasion process which have been published until mayo were completely revised. Results. Given that the bovine erythrocyte invasion process is key for the pathogenesis of bovine babesiosis, a review was made where 3 proteins were found to be associated to the recognition and invasion processes of target cells: MSA-1, AMA-1 and RON2. However, the details at molecular level for the inter an intramolecular interaction have not yet been fully elucidated. Conclusions. Study the molecules involved in host-parasite interactions will allow understanding how the B. bovis invasion process to erythrocytes occurs and evaluating their future utility as a component of an effective control strategy for this parasitosis.
Cuy Chaparro, Laura Esperanza
Camargo Mancipe, Anny
Gómez Rodríguez, Alida Marcela
Reyes Santofimio, César
Moreno Pérez, Darwin Andrés
Babesia bovis
Babesiosis
interacciones huésped-parásito
proteínas
control de infección
Babesia bovis
babesiosis
host-parasite interactions
proteins
infection control
Babesia bovis
babesiose
interações parasita-hospedeiro
proteínas
controle de infecção
8
1
Núm. 1 , Año 2021 : Revista Investigación en Salud Universidad de Boyacá
Artículo de revista
Journal article
2021-02-05T00:00:00Z
2021-02-05T00:00:00Z
2021-02-05
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Universidad de Boyacá
Revista Investigación en Salud Universidad de Boyacá
2389-7325
2539-2018
https://revistasdigitales.uniboyaca.edu.co/index.php/rs/article/view/475
10.24267/23897325.475
https://doi.org/10.24267/23897325.475
spa
http://creativecommons.org/licenses/by-nc/4.0
Revista Investigación en Salud Universidad de Boyacá - 2021
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
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institution UNIVERSIDAD DE BOYACÁ
thumbnail https://nuevo.metarevistas.org/UNIVERSIDADDEBOYACA/logo.png
country_str Colombia
collection Revista Investigación en Salud Universidad de Boyacá
title Proteínas importantes para la invasión de Babesia bovis a las células huésped
spellingShingle Proteínas importantes para la invasión de Babesia bovis a las células huésped
Cuy Chaparro, Laura Esperanza
Camargo Mancipe, Anny
Gómez Rodríguez, Alida Marcela
Reyes Santofimio, César
Moreno Pérez, Darwin Andrés
Babesia bovis
Babesiosis
interacciones huésped-parásito
proteínas
control de infección
Babesia bovis
babesiosis
host-parasite interactions
proteins
infection control
Babesia bovis
babesiose
interações parasita-hospedeiro
proteínas
controle de infecção
title_short Proteínas importantes para la invasión de Babesia bovis a las células huésped
title_full Proteínas importantes para la invasión de Babesia bovis a las células huésped
title_fullStr Proteínas importantes para la invasión de Babesia bovis a las células huésped
title_full_unstemmed Proteínas importantes para la invasión de Babesia bovis a las células huésped
title_sort proteínas importantes para la invasión de babesia bovis a las células huésped
title_eng Important proteins for Babesia bovis invasion to host cells
description Introducción. La babesiosis bovina es causada por parásitos Apicomplexa del género Babesia, siendo Babesia bovis la especie asociada con cuadros clínicos más graves de la enfermedad. La invasión de B. bovis a los eritrocitos bovinos implica la interacción entre moléculas de los merozoítos del parásito con receptores de las células huésped. Por ende, conocer las proteínas involucradas en este proceso supone un importante paso para entender la biología del parásito. Objetivo. Describir las principales moléculas implicadas en el proceso de invasión de B. bovis a eritrocitos bovinos. Metodología. Se realizó una búsqueda en NCBI, Medline, LILACS y SciELO usando los términos: “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving junction”, “B. bovis AND Vaccine candidates”. 61 publicaciones disponibles en inglés que describen el estudio de las anteriores proteínas y su participación en la invasión los cuales han sido publicados hasta mayo 2020 se revisaron completamente. Resultados: Siendo el proceso de invasión a eritrocitos bovinos clave para la patogénesis de la babesiosis bovina, se hizo una revisión donde se encontraron 3 proteínas de B. bovis que participan en el reconocimiento e invasión a las células diana: MSA-1, AMA-1 y RON2. Sin embargo, los detalles a nivel molecular para las interacciones inter e intramoleculares aún no se han dilucidado por completo. Conclusiones. Conocer las moléculas involucradas en las interacciones parásito-hospedero permitirá comprender cómo ocurre el proceso de invasión de B. bovis a los eritrocitos y así evaluar su futura utilidad como componente de una estrategia de control efectiva contra esta parasitosis.
description_eng Introduction. Bovine babesiosis is caused by Apicomplexas parasites of the genus Babesia, Babesia bovis being the species associated with the most serious clinical conditions of the disease. B. bovis invasion into the bovine erythrocytes involves the interaction between the parasites merozoites molecules with host cell receptors. Therefore, knowing the proteins involved in the invasion process will enable understanding the parasite biology. Objective. To describe the important molecules involved in the B. bovis invasion process to bovine erythrocytes. Methodology. A search was made on NCBI, Medline, LILACS and SciELO databases using keywords as “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving junction”, “B. bovis AND Vaccine candidates”. 61 studies written in English describing the study for proteins that take place during invasion process which have been published until mayo were completely revised. Results. Given that the bovine erythrocyte invasion process is key for the pathogenesis of bovine babesiosis, a review was made where 3 proteins were found to be associated to the recognition and invasion processes of target cells: MSA-1, AMA-1 and RON2. However, the details at molecular level for the inter an intramolecular interaction have not yet been fully elucidated. Conclusions. Study the molecules involved in host-parasite interactions will allow understanding how the B. bovis invasion process to erythrocytes occurs and evaluating their future utility as a component of an effective control strategy for this parasitosis.
author Cuy Chaparro, Laura Esperanza
Camargo Mancipe, Anny
Gómez Rodríguez, Alida Marcela
Reyes Santofimio, César
Moreno Pérez, Darwin Andrés
author_facet Cuy Chaparro, Laura Esperanza
Camargo Mancipe, Anny
Gómez Rodríguez, Alida Marcela
Reyes Santofimio, César
Moreno Pérez, Darwin Andrés
topicspa_str_mv Babesia bovis
Babesiosis
interacciones huésped-parásito
proteínas
control de infección
topic Babesia bovis
Babesiosis
interacciones huésped-parásito
proteínas
control de infección
Babesia bovis
babesiosis
host-parasite interactions
proteins
infection control
Babesia bovis
babesiose
interações parasita-hospedeiro
proteínas
controle de infecção
topic_facet Babesia bovis
Babesiosis
interacciones huésped-parásito
proteínas
control de infección
Babesia bovis
babesiosis
host-parasite interactions
proteins
infection control
Babesia bovis
babesiose
interações parasita-hospedeiro
proteínas
controle de infecção
citationvolume 8
citationissue 1
citationedition Núm. 1 , Año 2021 : Revista Investigación en Salud Universidad de Boyacá
publisher Universidad de Boyacá
ispartofjournal Revista Investigación en Salud Universidad de Boyacá
source https://revistasdigitales.uniboyaca.edu.co/index.php/rs/article/view/475
language spa
format Article
rights http://creativecommons.org/licenses/by-nc/4.0
Revista Investigación en Salud Universidad de Boyacá - 2021
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
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